What is RESOF Total 400mg/100mg Tablet?

RESOF Total is a combination antiviral medication containing Sofosbuvir (400mg) and Velpatasvir (100mg), used to treat chronic Hepatitis C Virus (HCV) infection. It is indicated for the treatment of HCV in adults with genotypes 1, 2, 3, 4, 5, and 6. This tablet works by inhibiting different stages of the Hepatitis C virus lifecycle, preventing the virus from replicating and spreading throughout the body. RESOF Total is part of a 12-week treatment regimen and is often prescribed to reduce the viral load, promote liver healing, and prevent complications associated with chronic HCV, such as liver cirrhosis or liver cancer.

Uses:

RESOF Total 400mg/100mg Tablet is used for:

• Treating chronic Hepatitis C infection in adults.
• Reducing the risk of liver damage, including cirrhosis and liver cancer, in patients with chronic HCV.
• Overseeing HCV contamination in patients regardless of cirrhosis.
• Enhancing the chances of a sustained virologic response (SVR), which indicates the virus has been eradicated from the body.

How Does RESOF Total 400mg/100mg Tablet Work?

RESOF Total contains two active ingredients:

1. Sofosbuvir (400mg): A nucleotide analog that inhibits the NS5B polymerase enzyme, which is crucial for the replication of the Hepatitis C virus.
2. Velpatasvir (100mg): An NS5A inhibitor that blocks a protein essential for the replication and assembly of the virus.

By targeting different steps in the virus’s lifecycle, these two agents work synergistically to stop the virus from multiplying, helping the body clear the infection. This results in a reduction in viral load and an improved liver function.

How to Use:

1.Dosage:

• Take one tablet once every day, regardless of food.
• It is best to take the tablet at the same time each day.

2.Treatment Duration:

• The typical treatment duration is 12 weeks, though the duration may vary depending on the severity of liver disease and other factors. Always follow your doctor’s guidance.

3.Adherence:

• Do not skip doses or stop treatment prematurely, even if you feel better. Consistency is vital to accomplishing the best outcomes.

Storage:

• Store RESOF Total tablets at room temperature (15–30°C).
• Keep the medicine in its unique bundling to shield it from dampness and light.
• Ensure that the container is tightly closed and keep out of reach of children.

Side Effects:

While RESOF Total is generally well-tolerated, some people may experience side effects, including:

• Fatigue
• Headache
• Nausea or stomach upset
• Insomnia (difficulty sleeping)
• Diarrhea

Rare but serious side effects:

• Allergic reactions (rash, swelling, difficulty breathing)
• Bradycardia (slow pulse), particularly when utilized with amiodarone
• Severe liver problems, especially in patients with advanced cirrhosis

Assuming you experience extreme secondary effects, contact your PCP right away.

General FAQs:

1. Can RESOF Total cure Hepatitis C?

Yes, RESOF Total is highly effective in curing chronic Hepatitis C infection when taken as prescribed. It achieves a sustained virologic response (SVR) in most patients, which indicates that the virus is no longer detectable in the blood.

2. Can RESOF Total be used for all HCV genotypes?

RESOF Total is effective for genotypes 1, 2, 3, 4, 5, and 6. For other genotypes, your doctor will prescribe an alternative treatment regimen if necessary.

3. Can I take RESOF Total with other medications?

Some medications may interact with RESOF Total, so it’s important to inform your doctor about all medications, including over-the-counter drugs and herbal supplements. Certain medications like antacids, rifampin, or amiodarone may interfere with the effectiveness of the treatment.

4. Is RESOF Total safe for pregnant or breastfeeding women?

The safety of RESOF Total during pregnancy and breastfeeding has not been well-established. Pregnant or breastfeeding women should consult a healthcare provider before starting this medication.

5. Are there any dietary restrictions while using RESOF Total?

There are no specific dietary restrictions. However, avoid consuming grapefruit or grapefruit juice, as it may affect the metabolism of the medication.

6. How long will it take to see results with RESOF Total?

The effects of RESOF Total may be seen within the first few weeks of treatment, with a substantial reduction in viral load. Full eradication of the virus and restoration of liver health usually require completing the prescribed treatment duration (12 weeks).

7. Can I still transmit Hepatitis C while taking RESOF Total?

While RESOF Total effectively treats the virus, it does not prevent reinfection or transmission to others. You should continue practicing safe sex and avoid sharing needles or other personal items to reduce the risk of transmission.