What is Ledviclear 90mg / 400mg Tablet?

Ledviclear 90mg / 400mg Tablet is a combination medication used for the treatment of chronic Hepatitis C Virus (HCV) infection. It contains two active ingredients:

• Ledipasvir (90mg): An NS5A inhibitor that prevents the replication and assembly of the Hepatitis C virus.
• Sofosbuvir (400mg): A nucleotide analog that inhibits the NS5B RNA polymerase, a critical enzyme for viral replication.

This combination therapy is used to treat chronic Hepatitis C in adults and is effective against all major genotypes of the virus (1–6), with or without liver cirrhosis.

Uses:

Ledviclear is prescribed for:

• Chronic Hepatitis C Virus infection, especially in individuals with or without cirrhosis (liver scarring).
• Genotypes 1 to 6 of the Hepatitis C infection.
• It is also used to reduce the risk of liver complications such as cirrhosis, liver failure, and liver cancer.
• This tablet is typically used in combination with other treatments for chronic HCV but can be used as monotherapy in some cases.

How Does Ledviclear 90mg / 400mg Tablet Work?

The two active ingredients work together to block the replication of the Hepatitis C virus:

1. Ledipasvir inhibits the NS5A protein, which is essential for the virus’s replication and assembly. By blocking this protein, Ledipasvir prevents the virus from replicating.
2. Sofosbuvir inhibits the NS5B RNA polymerase, which is necessary for the virus to replicate its RNA. By blocking this enzyme, Sofosbuvir effectively halts the viral replication process.

Together, these components help reduce the viral load in the body, improve liver function, and prevent long-term liver damage.

How to Use:

1.Dosage:

• Require one tablet once every day regardless of food.
• Gulp down the tablet with a glass of water. Try not to bite, pound, or break the tablet.

2.Treatment Duration:

• The standard treatment duration is usually 12 weeks, but your doctor may adjust this based on your liver condition or viral genotype.

3. Adherence:

• Take Ledviclear at the same time each day to maintain consistent levels in your bloodstream.
• Complete the full course of treatment as prescribed by your doctor to ensure the most effective results.

Storage:

• Store Ledviclear Tablets at room temperature (15–30°C), away from heat and moisture.
• Keep the tablets in the original packaging to protect them from light and humidity.
• Store out of reach of children and pets.

Side Effects:

Most people tolerate Ledviclear well, but some common side effects may include:

• Fatigue
• Headache
• Nausea
• Diarrhea
• Insomnia

Serious side effects (less common) may include:

• Bradycardia (slow heart rate), particularly if combined with medications like amiodarone.
• Severe allergic reactions (e.g., rash, swelling, difficulty breathing).
• Liver decompensation in patients with cirrhosis.

If you experience severe side effects or signs of an allergic reaction, stop taking the medication and contact your healthcare provider immediately.

General FAQs:

1. Is Ledviclear a cure for Hepatitis C?

Yes, Ledviclear is an effective treatment for chronic Hepatitis C. It can lead to a sustained virologic response (SVR), which means the virus is undetectable in the blood after completing the treatment course.

2. Can Ledviclear treat all genotypes of Hepatitis C?

Yes, Ledviclear is a pan-genotypic treatment, which is effective against all six major genotypes of Hepatitis C (1 to 6).

3. Can I take Ledviclear with other medications?

Certain medications may interact with Ledviclear, including other antiviral drugs, medications for heart conditions (such as amiodarone), and proton pump inhibitors (PPIs). Always inform your doctor about any other medications, supplements, or herbal products you are using.

4. Is Ledviclear safe during pregnancy or breastfeeding?

The safety of Ledviclear during pregnancy and breastfeeding is not well established.It is suggested that ladies of childbearing age utilize viable contraception during treatment.Consult your healthcare provider for advice if you are pregnant or breastfeeding.

5. Are there any dietary restrictions while taking Ledviclear?

There are no specific dietary restrictions. However, grapefruit and grapefruit juice should be avoided, as they may interfere with the metabolism of the medication.

6. How long does it take for Ledviclear to work?

While Ledviclear starts working right away, the full treatment duration (typically 12 weeks) is required for optimal results. Regular monitoring of your liver function and viral load is typically done during and after treatment.

7. Can Hepatitis C return after treatment with Ledviclear?

Reinfection is possible if you are exposed to the virus again. It is important to practice safe habits to reduce the risk of reinfection, such as not sharing needles or other drug-use equipment and using protection during sexual activity.